Global Grants

 

The Fleming Fund is working in collaboration with a number of partners through Global Grants to provide support to countries as they begin to tackle antimicrobial resistance (AMR).

Governance, policy and technical leadership

We have partnered with the triparite -  the Food and Agricultural Organization (FAO), World Organisation for Animal Health (OIE) and the World Health Organization (WHO), to promote a One Health approach to tackling antimicrobial resistance. One Health recognises the interconnections between human and animal health, and the environment.

These three organisations have been working through Fleming Fund grants to provide technical assistance, expertise for protocol development and support for policy and strategy creation since 2016.

This work will enable countries to progress towards collecting data on antimicrobial use and resistance which can be shared national and globally to influence changes to policy and practice. It will also ensure countries are better equipped with the strategies and tools needed to be in a better position to successfully apply for Fleming Fund Country Grants.

The Food and Agricultural Organization (FAO) is working to:

  • Support countries in Sub-Saharan Africa, South and South-East Asia to develop and implement National Action Plans.

  • Strengthen regulatory frameworks around AMR.

  • Strengthen laboratory capacity in the regional focus areas.

  • Support good practices in food and agriculture sectors and ensuring that these are implemented in target countries.

The World Organisation for Animal Health (OIE) is working to:

  • Improve recognition and awareness of the critical importance of tacking AMR amongst veterinary health professionals and the general public.

  • Agree OIE standards on AMR and progressing towards implementation of these standards in low and middle income countries.

  • Establish a baseline overview of antibiotic consumption and use in animals.

  • Improve the regulatory frameworks targeting veterinary medicines including antimicrobials.

The World Health Organization (WHO) is working to:

  • Support countries in Sub-Saharan Africa, South and South-East Asia to develop and implement National Action Plans.

  • Design and test a One Health surveillance protocol on AMR focused on the spread and containment of drug resistant Escherichia coli.

  • Develop, pilot and roll out methods for monitoring antibiotic consumption and use.

Links to additional information:

 

Harnessing the influence of civil society

 

South Centre - AMR meetings

The South Centre is a non-profit inter-governmental organization set up by leaders of low and middle income countries to conduct research and assist these countries in international affairs, as well as supporting them in national policy-making.

 

We have partnered with the South Centre through a grant to support policy engagement on AMR to raise awareness of the issue, and support action to tackle AMR. The centre will work with developing country governments directly to achieve this, as well as working with civil society in low and middle income countries to develop a societal awareness of this issue.

 

During the first year of the grant, the South Centre has engaged with an array of country missions and civil society networks, as well as in international events and conferences to improve understanding and political will to tackle AMR. This has included organising a regional conference in South-East Asia (SEA) bringing together representatives from SEA governments and national AMR committees, technical experts and regional civil society networks to share national experiences of addressing the issue.

 

 

Unlocking the power of data 

Global Burden of Disease - AMR project

The Global Burden of Disease Study (GBD) is a free, open access platform which uses mathematical modelling to estimate the levels of mortality and disability associated with major diseases around the world.

We are supporting the Global Burden of Disease team to collect and share data on the burden of morbidity and mortality caused by AMR.

A new collaboration to conduct geospatial modelling and develop maps of the likely burden of antimicrobial resistance is being funded by the UK Department of Health and Social Care via the Fleming Fund, the Wellcome Trust and the Bill and Melinda Gates Foundation.

The project will use complex geospatial modelling to improve understanding of the burden of disease associated with AMR in each country and therefore the public health threat that this poses.

Who is involved?

Scientists from the Big Data Institute and the Centre for Tropical Medicine and Global Health both at the University of Oxford, and researchers at the Institute for Health Metrics and Evaluation (IHME) University of Washington, will work together on the initiative.

“This ground-breaking collaboration will enable us to better understand the extent of death and disease that AMR is causing globally and will guide future efforts and allocation of resources globally.”
Steve Brine, UK Minister for Public Health and Primary Care

The Global Burden of Disease - AMR project will:

  • Gather and assemble data on selected bacteria-antibacterial drug combinations to create mathematical models.

  • Use the models to generate globally comparable AMR burden estimates for those “bug-drug” combinations from 1990 to the present for the 195 countries and territories included in the Global Burden of Disease study.

  • Produce heat-maps of modelled AMR burden that will allow policymakers and researchers to tailor future studies and interventions to the local level.

  • Provide free, public access to study results through interactive data visualisations.

"The health burden of AMR in the world is a critical global health issue, and we are motivated to get more accurate estimates on its true impact."
Professor Simon Hay, Director of IHME

(L-R) - Dr Tim Jinks (Wellcome Trust); Professor Christopher Murray (IHME); Professor Dame Sally Davies, Chief Medical Officer for England and Chief Medical Advisor to the UK Government, and Rt Hon Alistair Burt MP, Minister of State for International Development and Minister of State at the Foreign and Commonwealth Office.

How will the project contribute to the wider efforts to tackle AMR?

Use of modelling on the burden and distribution of AMR will enable researchers, policymakers, and health officials to:

  • Study past approaches to addressing AMR and replicate successful techniques.

  • Construct plans to reduce AMR across the globe.

  • Allocate resources – including potent drugs able to treat resistant infections – to areas of need.

  • Improve drug development planning.

  • Prescribe treatments that are targeted to the resistant microbes present locally.

  • Assess the baseline extent of the AMR problem.

 

Links:
http://www.ox.ac.uk/
https://www.bdi.ox.ac.uk/
http://www.tropicalmedicine.ox.ac.uk